Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases

Abstract

In addition to its proven effectiveness in the treatment
of recurrent Clostridium difficile infections (rCDI), fecal
microbiota transplantation (FMT) is on the rise to
become one of the most studied innovative therapies
for the treatment of several complex diseases. This review
aims to discuss the many promising applications
of FMT in intestinal diseases such as inflammatory
bowel diseases (IBD) and extraintestinal diseases such
as neuropsychiatric disorders, metabolic syndrome,
and autoimmune diseases. For each disease group, preclinical
data will be presented in addition to clinical
trial evidence.