Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases

Carlotta Magrì¹, Giuliana Calabrese¹, Letizia Masi², Sara Troisi¹, Federica di Vincenzo¹, Pierluigi Puca¹, Cristina Graziani², Loris R. Lopetuso^2,3,4, Valentina Petito²

¹Dipartimento Universitario di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
²Centro per le Malattie dell’Apparato Digerente (CeMAD), UOS di Malattie Infiammatorie Croniche Intestinali, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy.
³Dipartimento di Medicina e Scienze dell’Invecchiamento, Università degli studi “G. D’Annunzio”, Chieti-Pescara, Chieti, Italy.
⁴Center for Advanced Studies and Technology (CAST), Università degli studi “G. D’Annunzio”, Chieti-Pescara, Chieti, Italy.

Nutr Cur 2023; 02: e001

DOI: 10.57625/nec.2022.23

ABSTRACT

In addition to its proven effectiveness in the treatment of recurrent Clostridium difficile infections (rCDI), fecal microbiota transplantation (FMT) is on the rise to become one of the most studied innovative therapies for the treatment of several complex diseases. This review aims to discuss the many promising applications of FMT in intestinal diseases such as inflammatory bowel diseases (IBD) and extraintestinal diseases such as neuropsychiatric disorders, metabolic syndrome, and autoimmune diseases. For each disease group, preclinical data will be presented in addition to clinical trial evidence.

Corresponding author:

Valentina Petito

To cite this article: Magrì Carlotta, Calabrese Giuliana, Masi Letizia, Troisi Sara, Di Vincenzo Federica, Puca Pierluigi, Graziani Cristina, Lopetuso Loris R., Petito Valentina. Fecal microbiota transplantation: an update on the advances in the treatment of complex diseases. Nutr Cur 2022; 01: e131 – DOI: 10.57625/nec.2022.23

Publication history:

Submission date: 8th Dec, 2022
Revised on: 12th Dec, 2022
Accepted on: 15th Dec, 2022
Published online: 10th Jan, 2023

This work is licensed under a Creative Common Attribution-NonCommercial-ShareAlike 4.0 International License

Category: Review
Topic: Fecal microbial transplantation

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